The Science of Aging
Sinclair's research centers on sirtuins, NAD+, and the epigenome. He views aging as a loss of cellular information that can potentially be reversed. This framework has led to interest in peptides that may support cellular health and regeneration.
Epithalon and Telomeres
Epithalon is a synthetic tetrapeptide that research suggests may activate telomerase, the enzyme that maintains telomere length. Telomere shortening is associated with aging, making this a key area of longevity research.
GHK-Cu: The Regenerative Peptide
GHK-Cu (copper peptide) naturally occurs in the body but decreases with age. Research indicates it may help with wound healing, skin regeneration, and has shown anti-aging properties in studies. Sinclair has discussed its role in regenerative medicine.
Mitochondrial Peptides
MOTS-c is a mitochondrial-derived peptide that's gained attention for its potential metabolic benefits. Research suggests it may act as an exercise mimetic, supporting metabolic health and potentially lifespan.